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KMID : 0367420050480010081
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Journal of Korean Pediatric Society
2005 Volume.48 No. 1 p.81 ~ p.84
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A Case of Hypocomplementemic Henoch-Schonlein Purpura Presenting Features of Membranoproliferative Glomerulonephritis
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Lee Kyung-A
Ha Tae-Sun
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Abstract
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Henoch-Schonlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis that can affect multiple organs predominantly the skin, joints, gastrointestinal tract and kidney. Although the specific pathogenesis of HSP is not known, there are several hypotheses. Although the importance of the complement activation in glomerular injury in HSP has been suggested, the complement levels and the blood pressure in those patients are usually normal and massive proteinuria is not common. And pathologic renal changes also have been reported to show a large variety of glomerular changes. However, to our knowledge, a membranoproliferative glomerulo-nephritis (MPGN) is a rare renal clinicopathologic manifestation of HSP. We report a 6-year-old boy with HSP who developed MPGN with hypertension, massive proteinuria, and hypo-complementemia revealed activation of the classical complement pathway, although we could not exclude the possibility of other hypocomplementemic glomerulonephritis including post-streptococcal acute glomerulonephritis.
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KEYWORD
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Henoch-Schonlein purpura, Hypocomplementemic glomerulonephritis, membranoproliferative glomerulonephritis
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